protein 833 words KG: LAMP2
Contents

LAMP2 Protein

🔬 Protein Info
Gene SymbolLAMP2
AliasesLysosomal-Associated Membrane Protein 2
ChromosomeXq24
Protein FamilyLAMP family
FunctionLAMP2 encodes Lysosomal Associated Membrane Protein 2, a major lysosomal membrane glycoprotein essential for lysosomal function, autophagy, and chaperone-mediated autophagy (CMA).
Molecular Weight45 kDa
Amino Acids410 aa
PathwaysApoptosis, Autophagy, Chaperone, Lysosomal Degradation, Mtor
UniProt IDP13473
Ensembl IDENSG00000143106
GeneCardsLAMP2
Human Protein AtlasLAMP2
Associated DiseasesAls, Alzheimer, APOPTOSIS, AUTOPHAGY, Cancer
Known Drugs/Compoundsquercetin, rapamycin, RAPAMYCIN, statins
InteractionsACLY, ACOX1, ACTB, Adiponectin, ADIPOQ, AGING
SciDEX HypothesesLAMP2A Liquid-Liquid Phase Separation Defects in D
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Pre
KG Connections1100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (42)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
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Related Analyses (18)

Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

Neuroimmune modulation and Aβ clearance mechanisms
exploratory · proposed · Score: 0.82

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
ACTB Gene
gene · KG edge: regulates
AMBRA1 Gene
gene · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

VAMP8 associated_with LAMP2
LAMP2 associated_with GBM
LAMP2 associated_with LC3
LAMP2 associated_with EPG5
LAMP2 associated_with STX17
LAMP2 associated_with SQSTM1
LAMP2 associated_with SNAP29
LAMP2 associated_with SDC1
LAMP2 associated_with TGM2
GABARAP associated_with LAMP2

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