Contents

TGM2 — Transglutaminase 2

🧬 Gene Info

Gene Symbol	TGM2
Full Name	Transglutaminase 2
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitors of transglutaminase enzymatic activity
Mechanism of Action	Small molecule inhibitors of transglutaminase enzymatic activity
Primary Expression	various tissues, including the central nervous system, where it is particularly abundant in neurons and glial cells
Druggability	Medium (0.49)
Clinical Stage	Phase II
Molecular Weight	77 kDa
Amino Acids	687 aa
Pathways	Autophagy, G Protein Signaling, Histone Modification, neuronal differentiation
UniProt ID	A2A2A0
Ensembl ID	ENSG00000198959
GeneCards	TGM2
Human Protein Atlas	TGM2
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Cystamine Dihydrochloride, organophosphates, Urolithin A
Interactions	ACE2, Actin, Adiponectin, ADIPOQ, AGING, ALS
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Transglutaminase-2 Cross-Linking Inhibition Strate Low Complexity Domain Cross-Linking Inhibition
KG Connections	750 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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