gene 3,051 words KG: TAZ
Contents

TAZ (WWTR1)

🧬 Gene Info
Gene SymbolTAZ
Full NameWW Domain Containing Transcription Regulator 1
Chromosome3q24
Functionis a key transcriptional co-activator in the Hippo signaling pathway.
Amino Acids400 aa
PathwaysBlood-Brain Barrier, Complement, Epigenetic, Hedgehog, Hippo Pathway
UniProt ID[Q9GZV0](https://www.uniprot.org/uniprot/Q9GZV0)
Ensembl IDENSG00000118445
GeneCardsTAZ
Human Protein AtlasTAZ
isoform 1Full-length protein (400 amino acids)
Shorter isoformsGenerated through alternative splicing, these may have distinct functional properties
Associated DiseasesAls, Cancer, Carcinoma, Multiple Sclerosis, Neurodegeneration, Pancreatic Cancer
InteractionsAGING, AKT, AND, APC, APOPTOSIS, ATG
KG Connections217 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (32)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
APOE-Dependent Autophagy Restoration
Score: 0.88
Circadian Clock-Autophagy Synchronization
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Microglial Purinergic Reprogramming
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
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Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Mechanism: Selective Vulnerability of Dopaminergic Neurons i
validation · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (15)

blarcamesine-axon
clinical_trial · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
HDAC6 (Redirect)
redirect · KG edge: activates
Genes
index · KG edge: activates
APC Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TAZ regulates LATS1
TAZ regulates DDB1
TAZ protects_against PIEZO1
TAZ regulates MFSD2A
Hippo pathway regulates TAZ
LATS1 regulates TAZ
DRP1 regulates TAZ
NRF2 regulates TAZ
MIEF1 regulates TAZ
DDB1 regulates TAZ

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