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gene 1,181 words KG: MFSD2A
Contents

MFSD2A - Major Facilitator Superfamily Domain Containing 2A

🧬 Gene Info
Gene SymbolMFSD2A
Full NameMajor Facilitator Superfamily Domain Containing 2A
AliasesPage for MFSD2A
Chromosome1p34.2
Protein TypeTransporter
Functionencodes a sodium-dependent lysophosphatidylcholine (LPC) transporter that is essential for blood-brain barrier integrity and brain lipid composition.
Amino Acids530 aa
Exons14
PathwaysBlood-Brain Barrier
Ensembl IDENSG00000168389
GeneCardsMFSD2A
Human Protein AtlasMFSD2A
Associated Diseasesneurodegeneration
InteractionsCANCER, CAVEOLIN-1, CYTOKINES, INFLAMMATION, MICROGLIA, NEUROINFLAMMATION
KG Connections52 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Membrane Cholesterol Gradient Modulators
Score: 0.71Glycine-Rich Domain Competitive Inhibition
Score: 0.64Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Blood-Brain Barrier SPM Shuttle System
Score: 0.53Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: expressed_inAlzheimer Indonesia
institution · KG edge: expressed_inPackard Center for ALS Research
institution · KG edge: expressed_inAngiogenesis Pathway
mechanism · KG edge: inhibits

Knowledge Graph (12 edges)

TAZ regulates MFSD2A
STAT3 inhibits MFSD2A
WNT7A activates MFSD2A
MFSD2A inhibits PDGFRB
MFSD2A regulates Ischemia
MFSD2A activates Stroke
MFSD2A activates Ms
MFSD2A regulates Blood-Brain Barrier
MFSD2A inhibits CANCER
MFSD2A inhibits Tumor

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