gene 1,927 words KG: MIEF1
Contents

MIEF1 Gene

🧬 Gene Info
Gene SymbolMIEF1
Chromosome17q11.2
FunctionMIEF1 localizes to the mitochondrial outer membrane where it recruits Drp1 from the cytosol to the mitochondrial surface, initiating the fission process.
Primary ExpressionUbiquitous, highest in brain, heart, and muscle
Amino Acids463 aa
PathwaysComplement
UniProt IDQ9H0X6
NCBI Gene ID54443
Ensembl IDENSG00000135269
GeneCardsMIEF1
Human Protein AtlasMIEF1
Associated Diseasesneurodegeneration
InteractionsCANCER, DRP1, NRF2, OXIDATIVE STRESS
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.85
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (2)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: regulates
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: activates
NRF2 Gene
gene · KG edge: activates
TAZ (WWTR1)
gene · KG edge: regulates

Knowledge Graph (12 edges)

MIEF1 activates NRF2
MIEF1 activates DRP1
DRP1 regulates MIEF1
NRF2 regulates MIEF1
MIEF1 regulates TAZ
DRP1 activates MIEF1
MIEF1 activates Cancer
MIEF1 activates Oxidative Stress
SREBP1 regulates MIEF1
YAP regulates MIEF1

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