gene 3,051 words KG: TAZ
Contents

TAZ (WWTR1)

🧬 Gene Info
Gene SymbolTAZ
Full NameWW Domain Containing Transcription Regulator 1
Chromosome3q24
Functionis a key transcriptional co-activator in the Hippo signaling pathway.
Amino Acids400 aa
PathwaysBlood-Brain Barrier, Complement, Epigenetic, Hedgehog, Hippo Pathway
UniProt ID[Q9GZV0](https://www.uniprot.org/uniprot/Q9GZV0)
Ensembl IDENSG00000118445
GeneCardsTAZ
Human Protein AtlasTAZ
isoform 1Full-length protein (400 amino acids)
Shorter isoformsGenerated through alternative splicing, these may have distinct functional properties
Associated DiseasesAls, Cancer, Carcinoma, Multiple Sclerosis, Neurodegeneration, Pancreatic Cancer
InteractionsAGING, AKT, AND, APC, APOPTOSIS, ATG
KG Connections217 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (32)

CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
Oligodendrocyte White Matter Vulnerability
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
← Prevpg 2/2

Related Analyses (7)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Mechanism: Selective Vulnerability of Dopaminergic Neurons i
validation · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (15)

blarcamesine-axon
clinical_trial · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
HDAC6 (Redirect)
redirect · KG edge: activates
Genes
index · KG edge: activates
APC Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TAZ regulates LATS1
TAZ regulates DDB1
TAZ protects_against PIEZO1
TAZ regulates MFSD2A
Hippo pathway regulates TAZ
LATS1 regulates TAZ
DRP1 regulates TAZ
NRF2 regulates TAZ
MIEF1 regulates TAZ
DDB1 regulates TAZ

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