gene 562 words KG: SESN1
Contents

SESN1 Gene

🧬 Gene Info
Gene SymbolSESN1
Chromosome6q21<br>
FunctionSESN1 performs several critical cellular functions
Molecular Weight56 kDa
PathwaysmTOR, mtor, AMPK, AMPK signaling
UniProt IDQ9Y7X8
NCBI Gene ID27145
Ensembl IDENSG00000080589
GeneCardsSESN1
Human Protein AtlasSESN1
AMPK ActivationActivates AMPK to promote metabolic adaptation
Antioxidant DefenseInduces expression of antioxidant enzymes via NRF2
DNA Damage ResponseInduced by p53 in response to DNA damage
ProteostasisHelps maintain protein quality control
Associated DiseasesAlzheimer's Disease, Parkinson's Disease, Metabolic Syndrome, Cancer
InteractionsCCND1, CDKN1A, DUSP1, NDRG2, PPP5C, PRKAA2
KG Connections72 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
APOE-Dependent Autophagy Restoration
Score: 0.86
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: regulates
Genes
index · KG edge: regulates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

SESN1 regulates STING1
SESN1 regulates CGAS
PPP5C regulates SESN1
JUN regulates SESN1
ADRA1D regulates SESN1
PDK4 regulates SESN1
LITAF regulates SESN1
IL6R regulates SESN1
MERTK regulates SESN1
DUSP1 regulates SESN1

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