gene 2,724 words KG: PDK4
Contents

PDK4 (3-Phosphoinositide-Dependent Protein Kinase-4)

🧬 Gene Info
Gene SymbolPDK4
Chromosome7q21.3
Protein TypeKinase
Functionis a member of the phosphoinositide-dependent protein kinase (PDK) family that plays critical roles in regulating cellular metabolism, mitochondrial function, and survival.
Primary Expressiontissues with high metabolic demand, including heart, skeletal muscle, and brain
Amino Acids404 aa
Exons10
PathwaysAutophagy, Cell Cycle, Immune Response, Mtor
Ensembl IDENSG00000101447
GeneCardsPDK4
Human Protein AtlasPDK4
Associated DiseasesMs
InteractionsFERROPTOSIS, UBIQUITIN
KG Connections94 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.88
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
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Related Analyses (7)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
Genes
index · KG edge: regulates
ADCY9 Gene
gene · KG edge: regulates
ADRA1D Gene
gene · KG edge: regulates
BAX Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SOD2 associated_with PDK4
CAT associated_with PDK4
BAX associated_with PDK4
SPR associated_with PDK4
PPARGC1A associated_with PDK4
CASP3 associated_with PDK4
PDK1 associated_with PDK4
PDK4 associated_with SOD1
PDK4 associated_with TNFR2
PDK4 associated_with BCL2

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