gene 608 words KG: RELA
Contents

RELA (NF-κB p65)

🧬 Gene Info
Gene SymbolNF
Full NameκB p65 Protein
AliasesNF-κB p65
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight65 kDa
PathwaysNF-κB, NF-κB signaling
UniProt ID[P06579](https://www.uniprot.org/uniprot/P06579)
GeneCardsNF
Human Protein AtlasNF
RELA (p65)Primary transcriptional activator
REL (c-Rel)Lymphoid-specific subunit
RELBInducible subunit
NF-κB1 (p50/p105)Constitutive subunit
Associated DiseasesAging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/CompoundsRESVERATROL
InteractionsAKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections755 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (196)

Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
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Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
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Pharmacological Enhancement of APOE4 Glycosylation
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Vagal Afferent Microbial Signal Modulation
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Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Sphingolipid Metabolism Reprogramming
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TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
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Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: co_discussed
ABCG1 Gene
gene · KG edge: co_discussed
ACTB Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

NRF2 inhibits RELA
P38 activates RELA
IL1B activates RELA
PRDX1 activates RELA
TRAF6 activates RELA
CHUK activates RELA
PRDX6 activates RELA
MAPK14 activates RELA
BECN1 activates RELA
TNF activates RELA

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