gene 608 words KG: RELA
Contents

RELA (NF-κB p65)

🧬 Gene Info
Gene SymbolNF
Full NameκB p65 Protein
AliasesNF-κB p65
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight65 kDa
PathwaysNF-κB, NF-κB signaling
UniProt ID[P06579](https://www.uniprot.org/uniprot/P06579)
GeneCardsNF
Human Protein AtlasNF
RELA (p65)Primary transcriptional activator
REL (c-Rel)Lymphoid-specific subunit
RELBInducible subunit
NF-κB1 (p50/p105)Constitutive subunit
Associated DiseasesAging, Als, Cancer, Glioblastoma, Hepatitis, Inflammation
Known Drugs/CompoundsRESVERATROL
InteractionsAKT, AKT1, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AND
KG Connections750 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (196)

Gamma entrainment therapy to restore hippocampal-cortical sy
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Circadian Glymphatic Entrainment via Targeted Orexin Recepto
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AMPK hypersensitivity in astrocytes creates enhanced mitocho
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Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
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Selective APOE4 Degradation via Proteolysis Targeting Chimer
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Senescent Microglia Resolution via Maresins-Senolytics Combi
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Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
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Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
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Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Chromatin Accessibility Restoration via BRD4 Modulation
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APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
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Circadian Clock-Autophagy Synchronization
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Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
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CRISPR-based therapeutic approaches for neurodegenerative di
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Blood-brain barrier transport mechanisms for antibody therap
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Tau propagation mechanisms and therapeutic interception poin
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See Also (12)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: co_discussed
ABCD3 Gene
gene · KG edge: co_discussed
ABCG1 Gene
gene · KG edge: co_discussed
ACTB Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

NRF2 inhibits RELA
P38 activates RELA
IL1B activates RELA
PRDX1 activates RELA
TRAF6 activates RELA
CHUK activates RELA
PRDX6 activates RELA
MAPK14 activates RELA
BECN1 activates RELA
TNF activates RELA

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