| Gene Symbol | PTEN |
| Chromosome | 10 |
| Function | is a critical tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway, playing essential roles in neuronal survival, synaptic plasticity, and cellular homeostasis[@pten2021]. |
| Molecular Weight | 47 kDa |
| Amino Acids | 403 aa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone |
| GeneCards | PTEN |
| Human Protein Atlas | PTEN |
| Promoter region | Rich in CpG islands, subject to epigenetic regulation |
| Exon 5 | Contains the catalytic phosphatase domain (phosphatase core motif HCXXGXR) |
| C-terminal tail | Regulatory domain with multiple phosphorylation sites |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | circRNA, dimethyl fumarate, metformin, quercetin, rapamycin, RAPAMYCIN |
| Interactions | ABCD3, ABP, ACETYL-COA, Actin, ACVR1, ADSL |
| KG Connections | 2529 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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