| Gene Symbol | NR4A1 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Amino Acids | 598 aa |
| Exons | 7 coding exons spanning approximately 9.5 kb |
| Pathways | Autophagy, Mitophagy, Immune Response, Ferroptosis, Complement |
| Ensembl ID | ENSG00000123358 |
| GeneCards | NR4A1 |
| Human Protein Atlas | NR4A1 |
| Promoter | Contains multiple response elements including CRE, SRE, and GRE sites |
| Alternative splicing | Produces multiple transcript variants |
| Full-length NR4A1 (Nur77) | 598 amino acids |
| Synaptic activity | Calcium influx, NMDA receptor activation |
| Growth factors | NGF, BDNF, EGF |
| Stress signals | cAMP, forskolin |
| Associated Diseases | Aging, Als, Inflammation, Ms, Neurodegeneration |
| Interactions | AKT, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, App, ARC |
| KG Connections | 125 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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