gene 1,278 words KG: S100B
Contents

S100B Gene

🧬 Gene Info
Gene SymbolS100B
Full NameS100 Calcium Binding Protein B
Chromosome21q22.3
Protein FamilyS100 EF-hand calcium binding proteins
Functionis a gene encoding a calcium-binding protein of the S100 family, playing crucial roles in neuronal function, astrocyte biology, and neuroinflammation.
Molecular Weight10.5 kDa
Amino Acids92 aa
PathwaysPI3K
UniProt ID[P16401](https://www.uniprot.org/uniprot/P16401)
Ensembl IDENSG00000122574
OMIM176990
GeneCardsS100B
Human Protein AtlasS100B
Associated DiseasesAls, Cardiovascular, Glioma, Inflammation, Ms, Neurodegeneration
InteractionsAdiponectin, ADIPOQ, ALZHEIMER, AMYLOID, AND, APOPTOSIS
SciDEX HypothesesS100B as Active Pathogenic BBB-Disrupting Signal v
KG Connections363 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Glial Glycocalyx Remodeling Therapy
Score: 0.65
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Aquaporin-4 Polarization Rescue
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (8)

Neuroinflammation and microglial priming in early AD
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (11)

Astrocytes
cell · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: co_discussed
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: associated_with

Knowledge Graph (12 edges)

FGF21 biomarker_for S100B
APP activates S100B
FNDC5 biomarker_for S100B
S100B biomarker_for PLAU
S100B biomarker_for CXCL10
S100B activates C1Q
S100B biomarker_for CX3CL1
S100B biomarker_for VIM
S100B biomarker_for BDNF
S100B activates TGM2

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