gene 968 words KG: LC3
Contents

MAP1LC3A Gene

🧬 Gene Info
Gene SymbolLC3
AliasesMicrotubule-Associated Protein 1 Light Chain 3
Protein TypeTranscription Factor
FunctionLC3 is essential for autophagosome formation and function
Molecular Weight17 kDa
PathwaysAkt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
GeneCardsLC3
Human Protein AtlasLC3
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin
Interactions6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1
KG Connections3247 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (75)

Circadian Glymphatic Rescue Therapy (Melatonin-focused)
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Orexin-Microglia Modulation Therapy
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Hypocretin-Neurogenesis Coupling Therapy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
← Prevpg 4/4

Related Analyses (17)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (21)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40

See Also (6)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABCG1 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

FOXO3 regulates LC3
autophagy_pathway regulates LC3
ACTB interacts_with LC3
P2RY12 activates LC3
APOA1 interacts_with LC3
ULK1 interacts_with LC3
EIF4EBP1 interacts_with LC3
LC3 inhibits MTOR
LC3 interacts_with ABCG1
LC3 activates SQSTM1

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