gene 968 words KG: LC3
Contents

MAP1LC3A Gene

🧬 Gene Info
Gene SymbolLC3
AliasesMicrotubule-Associated Protein 1 Light Chain 3
Protein TypeTranscription Factor
FunctionLC3 is essential for autophagosome formation and function
Molecular Weight17 kDa
PathwaysAkt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
GeneCardsLC3
Human Protein AtlasLC3
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin
Interactions6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1
KG Connections3246 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (75)

Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
VCP-Mediated Autophagy Enhancement
Score: 0.59
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Cryptic Exon Silencing Restoration
Score: 0.53
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Adenosine-Astrocyte Metabolic Reset
Score: 0.73
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
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Related Analyses (17)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (21)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40

See Also (6)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABCG1 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

FOXO3 regulates LC3
autophagy_pathway regulates LC3
ACTB interacts_with LC3
P2RY12 activates LC3
APOA1 interacts_with LC3
ULK1 interacts_with LC3
EIF4EBP1 interacts_with LC3
LC3 inhibits MTOR
LC3 interacts_with ABCG1
LC3 activates SQSTM1

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