gene 968 words KG: LC3
Contents

MAP1LC3A Gene

🧬 Gene Info
Gene SymbolLC3
AliasesMicrotubule-Associated Protein 1 Light Chain 3
Protein TypeTranscription Factor
FunctionLC3 is essential for autophagosome formation and function
Molecular Weight17 kDa
PathwaysAkt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
GeneCardsLC3
Human Protein AtlasLC3
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsATTECs, CISPLATIN, dimethyl fumarate, licorice, nicotinamide, rapamycin
Interactions6-OHDA, ABCA1, ABCD3, ABCG1, ABP, ACAT1
KG Connections3246 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (75)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Stress Granule Phase Separation Modulators
Score: 0.72
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
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Related Analyses (17)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (21)

P2RY12 regulation of autophagy in VSMCs
exploratory · proposed · Score: 0.90
CLOCK/BMAL1 regulation of ICC autophagy in GERD model
exploratory · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40

See Also (6)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCD3 Gene
gene · KG edge: interacts_with
ABCG1 Gene
gene · KG edge: interacts_with
ACTB Gene
gene · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in

Knowledge Graph (12 edges)

FOXO3 regulates LC3
autophagy_pathway regulates LC3
ACTB interacts_with LC3
P2RY12 activates LC3
APOA1 interacts_with LC3
ULK1 interacts_with LC3
EIF4EBP1 interacts_with LC3
LC3 inhibits MTOR
LC3 interacts_with ABCG1
LC3 activates SQSTM1

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