| Gene Symbol | IFIH1 |
| Protein Type | Receptor |
| Function | encodes a critical cytoplasmic RNA helicase that serves as a pattern recognition receptor for viral RNA. |
| Primary Expression | neurons, astrocytes, and microglia - Upregulated during viral infections - Elevated in neurodegenerative |
| Pathways | Interferon Signaling |
| Ensembl ID | ENSG00000165178 |
| GeneCards | IFIH1 |
| Human Protein Atlas | IFIH1 |
| Ligand recognition | Long dsRNA (>1 kb), viral dsRNA genomes |
| Specificity | Picornaviruses, rotaviruses, noroviruses, some flaviviruses |
| Activation | Binding to viral RNA induces conformational changes |
| Oligomerization | Activated MDA5 forms filaments on dsRNA |
| Signaling | CARD domains interact with MAVS on mitochondria |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, GNAI1 |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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