| Gene Symbol | GNAI2 |
| Full Name | G Protein Subunit Alpha I2 |
| Chromosome | 3p21.31 |
| Function | Gαi2 is an inhibitory G protein that mediates signaling from various G protein-coupled receptors (GPCRs): |
| Primary Expression | the nervous system and plays crucial roles in neuronal signal transduction, synaptic plasticity, and cellular homeostasis[@gnai] |
| Pathways | PI3K |
| UniProt ID | [P04899](https://www.uniprot.org/uniprot/P04899) |
| Ensembl ID | ENSG00000128283 |
| GeneCards | GNAI2 |
| Human Protein Atlas | GNAI2 |
| GTPase domain | Contains the nucleotide-binding pocket and hydrolyzes GTP |
| Switch regions I-III | Conformational changes enable effector interactions |
| N-terminal helix | Mediates interaction with Gβγ dimer and membrane association |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, AKT1, AND, APOPTOSIS, AQP4, AQUAPORIN-4 |
| KG Connections | 45 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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