| Gene Symbol | GNAI1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | both excitatory pyramidal neurons and inhibitory interneurons - Subcellular: Primarily plasma membrane with some cytosolic lo |
| Molecular Weight | 40.4 kDa |
| Pathways | Autophagy, Wnt, Akt |
| GeneCards | GNAI1 |
| Human Protein Atlas | GNAI1 |
| Inhibitory signaling | Inhibits adenylyl cyclase activity, reducing cAMP production |
| GTP binding and hydrolysis | Classic G protein cycle with intrinsic GTPase activity |
| Effector pathways | Inhibits AC, activates GIRK channels, modulates phospholipase C |
| Pertussis toxin sensitive | Cysteine near C-terminus is ADP-ribosylated by PTX |
| cAMP modulation | Reduced cAMP affects memory consolidation and LTP |
| GIRK activation | Opens potassium channels causing neuronal hyperpolarization |
| βγ dimers | Releases Gβγ subunits that have independent signaling functions |
| Protein-protein interactions | Multiple effector interactions beyond AC |
| Associated Diseases | Als, Schizophrenia |
| Interactions | AKT, AKT1, ATG16L1, ATG5, AUTOPHAGY, GNAI2 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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