Contents

POLE — DNA Polymerase Epsilon

🧬 Gene Info

Gene Symbol	POLE
Full Name	DNA Polymerase Epsilon
Chromosome	12q24.3
Function	is a gene located on chromosome 12q24.
Primary Expression	Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra
Molecular Weight	261 kDa
Amino Acids	2308 aa
Pathways	Apoptosis, Blood-Brain Barrier, Er Stress, Ferroptosis, Inflammasome
UniProt ID	Q07864
NCBI Gene ID	5426
Ensembl ID	ENSG00000177042
OMIM	174762
GeneCards	POLE
Human Protein Atlas	POLE
Associated Diseases	Aging, Anxiety, Cancer, Depression, Epilepsy, Neurodegeneration
Interactions	Actin, AND, APOPTOSIS, ASTROCYTE, ATP, BAX
KG Connections	242 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph

POLE activates TREM2

POLE activates NLRP3

POLE activates TLR4

POLE activates GSDMD

POLE activates MYD88

MYD88 activates POLE

NLRP3 activates POLE

TREM2 activates POLE

GSDMD activates POLE

JUN activates POLE