gene 1,593 words KG: GNAL
Contents

GNAL — Gαolf Subunit

🧬 Gene Info
Gene SymbolGNAL
Full NameGαolf Subunit
Chromosome18p11.21
Functionencodes the Gαolf protein (Guanine nucleotide-binding protein subunit alpha L), a member of the Gαs family of heterotrimeric G proteins
Primary ExpressionNeuron-specific (olfactory epithelium, striatum)
Molecular Weight44 kDa
Exons12
UniProt ID[P38405](https://www.uniprot.org/uniprot/P38405)
Ensembl IDENSG00000141449
GeneCardsGNAL
Human Protein AtlasGNAL
Chromosomal location18p11.21
Genomic span~67 kb, 12 exons
Associated DiseasesAls
InteractionsCAMKII, CCND1, CYTOKINES, IL1B, IL3, IL8
KG Connections145 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (187)

SASP-Mediated Cholinergic Synapse Disruption
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Cell-Type Specific TREM2 Upregulation in DAM Microglia
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Targeted APOE4-to-APOE3 Base Editing Therapy
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Transcriptional Autophagy-Lysosome Coupling
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Multi-Modal Stress Response Harmonization
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Senescence-Activated NAD+ Depletion Rescue
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GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Smartphone-Detected Motor Variability Correction
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
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Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: co_discussed
Amyotrophic Lateral Sclerosis
redirect · KG edge: co_discussed
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: co_discussed
Apoptosis in Neurodegeneration
entity · KG edge: co_discussed
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: co_discussed

Knowledge Graph (12 edges)

GNAL expressed_in VAMP7
GNAL expressed_in MMP9
GNAL inhibits PI3K
GNAL associated_with AKT
GNAL associated_with AKT1
GNAL expressed_in MCC
GNAL expressed_in CXCR4
GNAL associated_with ALDH1A3
GCH1 associated_with GNAL
THAP1 associated_with GNAL

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