gene 610 words KG: TIMP1
Contents

TIMP1 Gene

🧬 Gene Info
Gene SymbolTIMP1
FunctionTIMP1 encodes tissue inhibitor of metalloproteinases 1, a member of the TIMP family that regulates matrix metalloproteinases (MMPs).
Primary Expressionastrocytes and can be induced by injury and inflammation
PathwaysAutophagy, Angiogenesis, senescence, oxidative stress response, circadian regulation
Ensembl IDENSG00000102265
GeneCardsTIMP1
Human Protein AtlasTIMP1
Associated Diseasesneurodegeneration
InteractionsANXA2, ASTROCYTES, ATF3, BMAL1, C3, CD14
KG Connections85 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (20)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (8)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed

See Also (15)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
IL6 (Redirect)
redirect · KG edge: regulates
Microglia in Neurodegeneration
entity · KG edge: activates
Genes
index · KG edge: expressed_in

Knowledge Graph (12 edges)

EZH2 regulates TIMP1
TIMP1 inhibits MMP9
substance P inhibits TIMP1
TIMP1 protects_against neuropathic pain
IL12B expressed_in TIMP1
ITPR1 expressed_in TIMP1
MAP1LC3B expressed_in TIMP1
ANXA2 activates TIMP1
ICAM1 activates TIMP1
CD44 activates TIMP1

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