gene 724 words KG: CHL1
Contents

CHL1 Gene

🧬 Gene Info
Gene SymbolCHL1
Full NameCHL1 Neural Cell Adhesion Molecule
Chromosome3p26.3
Functionencodes a neural cell adhesion molecule belonging to the L1 family of immunoglobulin superfamily CAMs.
Primary Expressionthe nervous system:
Molecular Weight200 kDa
Amino Acids209 aa
UniProt IDP0CAT4
NCBI Gene ID10752
Ensembl IDENSG00000113838
OMIM300114
GeneCardsCHL1
Human Protein AtlasCHL1
Extracellular domainContains 6 Ig-like domains and 5 fibronectin type III repeats, mediating homophilic and heterophilic interactions
Transmembrane domainSingle pass transmembrane region
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (6)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Membrane Cholesterol Gradient Modulators
Score: 0.71
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
BACE1 (Redirect)
redirect · KG edge: associated_with
GATA2 - GATA Binding Protein 2
gene · KG edge: therapeutic_target
PDGFRB — Platelet Derived Growth Factor Receptor Beta
gene · KG edge: associated_with
TIMP1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TIMP1 associated_with CHL1
GATA2 therapeutic_target CHL1
PDGFRB associated_with CHL1
APP mediates CHL1
BACE1 co_mentioned CHL1
VPS35 regulates CHL1
BACE1 targets CHL1
CHL1 targets epilepsy
ALZHEIMER'S DISEASE therapeutic_target CHL1
IMMUNE INFILTRATION therapeutic_target CHL1

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