gene 1,384 words KG: NFATC1
Contents

NFATc1 — Nuclear Factor of Activated T Cells 1

🧬 Gene Info
Gene SymbolNFATc1 / NFATC1
AliasesNuclear Factor of Activated T Cells 1
Chromosome18q23
Protein TypeTranscription Factor
Functionencodes a member of the NFAT family of calcium-dependent transcription factors.
PathwaysCalcium Signaling, Hippo Pathway
UniProt IDO95644
NCBI Gene ID4776
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsACSL4, AKT, AND, APOPTOSIS, AQP3, AUTOPHAGY
KG Connections39 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Aquaporin-4 Polarization Rescue
Score: 0.73
Extracellular Matrix Stiffness Modulation
Score: 0.69
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibits
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: inhibits
Genes
index · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: regulates

Knowledge Graph (12 edges)

PIEZO1 activates NFATC1
NFATC1 activates TRPC6
RANKL activates NFATC1
TXNRD1 activates NFATC1
NFATC1 activates SLC7A11
AQP4 regulates NFATC1
GATA3 regulates NFATC1
GATA2 regulates NFATC1
NFATC1 activates MST1
RANKL inhibits NFATC1

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