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gene 1,321 words KG: ALS9
Contents

ALS9 - Amyotrophic Lateral Sclerosis 9

🧬 Gene Info
Gene SymbolALS9
Full NameAmyotrophic Lateral Sclerosis 9
AliasesPage for ALS9
Chromosome14q11.2
Protein TypeSecreted ribonuclease
Functionis a genetic subtype of familial amyotrophic lateral sclerosis caused by mutations in the ANG gene (Angiogenin).
Primary ExpressionBroad, high in liver, brain, and motor neurons
Molecular Weight14.9 kDa
Amino Acids147 aa
PathwaysPI3K
UniProt IDP03950
Ensembl IDENSG00000100939
OMIM105400
GeneCardsALS9
Human Protein AtlasALS9
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections21 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (8)

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Cryptic Exon Silencing Restoration
Score: 0.53Phase-Separated Organelle Targeting
Score: 0.73

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (26)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_withNeurodegeneration
disease · KG edge: implicated_inFUS (Redirect)
redirect · KG edge: associated_withSOD1 (Redirect)
redirect · KG edge: associated_withDNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with

Knowledge Graph (12 edges)

ALS2 associated_with ALS9
FIG4 associated_with ALS9
FUS associated_with ALS9
ALS8 associated_with ALS9
ALSIN associated_with ALS9
ALS4 associated_with ALS9
ALS9 associated_with TARDBP
ALS9 associated_with ALS7
ALS9 associated_with ALS10
ALS9 associated_with SOD1

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