gene 883 words KG: ALS7
Contents

ALS7 - Amyotrophic Lateral Sclerosis 7

🧬 Gene Info
Gene SymbolALS7
Full NameALS7 - Amyotrophic Lateral Sclerosis 7
AliasesPage for ALS7
Chromosome20p13
Protein TypeGene
Functionis a genetic locus associated with familial amyotrophic lateral sclerosis (FALS)
Gene TypeProtein-coding (exact gene product under investigation)
OMIM607350
GeneCardsALS7
Human Protein AtlasALS7
Inheritance PatternAutosomal dominant
Central nervous systemMotor cortex, spinal cord (motor neurons), hippocampus
Peripheral tissuesVarious organs with highest expression in nervous system tissue
Cellular localizationCytoplasmic and nuclear compartments
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections21 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Cross-Seeding Prevention Strategy
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (23)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Neurodegeneration
disease · KG edge: implicated_in
FUS (Redirect)
redirect · KG edge: associated_with
SOD1 (Redirect)
redirect · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_with

Knowledge Graph (12 edges)

ALS2 associated_with ALS7
FIG4 associated_with ALS7
FUS associated_with ALS7
ALS8 associated_with ALS7
ALSIN associated_with ALS7
ALS4 associated_with ALS7
ALS9 associated_with ALS7
TARDBP associated_with ALS7
ALS7 associated_with ALS10
ALS7 associated_with SOD1

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