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gene 1,195 words KG: ALS10
Contents

ALS10 - Amyotrophic Lateral Sclerosis 10 (TARDBP)

🧬 Gene Info
Gene SymbolALS10
Full NameAmyotrophic Lateral Sclerosis 10 (TARDBP)
Chromosome1p36.22
Functionis a genetic locus associated with familial amyotrophic lateral sclerosis caused by mutations in the TARDBP gene (TAR DNA-Binding Protein).
Amino Acids414 aa
Gene TypeProtein coding
UniProt IDQ13148
NCBI Gene ID23435
Ensembl IDENSG00000120910
OMIM612069
GeneCardsALS10
Human Protein AtlasALS10
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Glaucoma
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (23)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40Environmental Exposure Causal Attribution in ALS — Experimen
validation · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

See Also (15)

FIG4 — FIG4 Phosphatase Homolog
gene · KG edge: associated_withTARDBP — TAR DNA Binding Protein 43
gene · KG edge: associated_withALS9 - Amyotrophic Lateral Sclerosis 9
gene · KG edge: associated_withAlsin (ALSIN)
gene · KG edge: associated_withGene Page: ALS4 (SENATAXIN)
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ALS2 associated_with ALS10
FIG4 associated_with ALS10
FUS associated_with ALS10
ALS8 associated_with ALS10
ALSIN associated_with ALS10
ALS4 associated_with ALS10
ALS9 associated_with ALS10
TARDBP associated_with ALS10
ALS7 associated_with ALS10
ALS10 associated_with SOD1

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