Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C-ABL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet.
No AI portrait yet
| Name | C-ABL |
| Key Genes/Proteins | ALPHA-SYNUCLEIN, AMPK, AND, ATM, CDK5, DJ-1 |
| Related Diseases | Als, Ataxia, Ms |
| Related Pathways | Necroptosis |
graph TD
C_ABL["C-ABL"]
C_ABL -->|"phosphorylates"| ZNF746["ZNF746"]
C_ABL -->|"activates"| Parkinson["Parkinson"]
C_ABL -->|"activates"| Als["Als"]
C_ABL -->|"inhibits"| RIPK3["RIPK3"]
C_ABL -->|"activates"| MLKL["MLKL"]
C_ABL -->|"activates"| Necroptosis["Necroptosis"]
GBA["GBA"] -->|"activates"| C_ABL
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| C_ABL
AND["AND"] -->|"inhibits"| C_ABL
GBA1["GBA1"] -->|"activates"| C_ABL
PARKINSON["PARKINSON"] -->|"activates"| C_ABL| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:C-ABL | data_in | dataset_row | 0.00 |
| ZNF746 | phosphorylates | gene | 0.90 |
| Als | activates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| RIPK3 | inhibits | gene | 0.60 |
| MLKL | activates | gene | 0.60 |
| Necroptosis | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:C-ABL | data_in | dataset_row | 0.00 |
| PARKINSON | associated_with | gene | 0.60 |
| PKC | associated_with | gene | 0.60 |
| OVERVIEW | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| PARKIN | associated_with | gene | 0.60 |
| CDK5 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| RET | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| DJ-1 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
| PTEN-INDUCED PUTATIVE KINASE 1 | associated_with | gene | 0.60 |
| PTEN | associated_with | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| GBA | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| GBA1 | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| c-Abl Tyrosine Kinase Activation Drives α-Synuclein Phosphor | 0.605 | neurodegeneration | Legacy Pre-Pipeline Hypothesis Import |
| Selective c-Abl Inhibition Promotes α-Synuclein Clearance vi | 0.580 | neurodegeneration | Test Hypothesis Fixtures |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning C-ABL in their description or question text
No additional research found