disease

hand

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about hand: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

4Hypotheses

1Analyses

50Outgoing

9Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    hand["hand"]
    TUMOR["TUMOR"]
    hand -->|"regulates"| TUMOR
    Neuroinflammatory["Neuroinflammatory"]
    hand -->|"regulates"| Neuroinflammatory
    FLAVONOIDS["FLAVONOIDS"]
    hand -->|"regulates"| FLAVONOIDS
    GLUCOSE_METABOLISM["GLUCOSE METABOLISM"]
    hand -->|"regulates"| GLUCOSE_METABOLISM
    microglia["microglia"]
    hand -->|"activates"| microglia
    microglia["microglia"]
    hand -->|"regulates"| microglia
    MITOCHONDRIA["MITOCHONDRIA"]
    hand -->|"activates"| MITOCHONDRIA
    Neurodegeneration["Neurodegeneration"]
    hand -->|"inhibits"| Neurodegeneration
    SCHIZOPHRENIA["SCHIZOPHRENIA"]
    hand -->|"inhibits"| SCHIZOPHRENIA
    mTOR["mTOR"]
    hand -->|"inhibits"| mTOR
    ISCHEMIA["ISCHEMIA"]
    hand -->|"inhibits"| ISCHEMIA
    NEURONS["NEURONS"]
    hand -->|"inhibits"| NEURONS
    Proteins["Proteins"]
    hand -->|"associated with"| Proteins
    cancer["cancer"]
    hand -->|"activates"| cancer
    TUMOR["TUMOR"]
    hand -->|"activates"| TUMOR
    Tumor_Microenvironment["Tumor Microenvironment"]
    hand -->|"activates"| Tumor_Microenvironment
    ferroptosis["ferroptosis"]
    hand -->|"associated with"| ferroptosis
    CELL_DEATH["CELL DEATH"]
    hand -->|"associated with"| CELL_DEATH
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    hand -->|"associated with"| Reactive_Oxygen_Species
    SNAP29["SNAP29"]
    hand -->|"inhibits"| SNAP29
    STX17["STX17"]
    hand -->|"inhibits"| STX17
    VAMP8["VAMP8"]
    hand -->|"inhibits"| VAMP8
    SNARE["SNARE"]
    hand -->|"inhibits"| SNARE
    Pyroptosis["Pyroptosis"]
    hand -->|"activates"| Pyroptosis
    Necroptosis["Necroptosis"]
    hand -->|"activates"| Necroptosis
    Neuron["Neuron"]
    hand -->|"activates"| Neuron
    White_Matter["White Matter"]
    hand -->|"activates"| White_Matter
    MOTOR_NEURON["MOTOR NEURON"]
    hand -->|"activates"| MOTOR_NEURON
    disease["disease"]
    hand -->|"causes"| disease
    Proteins["Proteins"]
    hand -->|"activates"| Proteins

Outgoing (59)

Target	Relation	Type	Str
NEUROINFLAMMATION	expressed_in	entity	0.60
SNAP29	degrades	entity	0.60
STX17	degrades	entity	0.60
VAMP8	degrades	entity	0.60
MSA	associated_with	entity	0.60
PHAGOCYTOSIS	degrades	entity	0.60
NEURODEGENERATION	inhibits	entity	0.60
SCHIZOPHRENIA	inhibits	entity	0.60
MTOR	inhibits	entity	0.60
CELL DEATH	associated_with	concept	0.50
Reactive Oxygen Species	associated_with	process	0.50
microglia	activates	cell_type	0.50
microglia	regulates	cell_type	0.50
Pyroptosis	activates	pathway	0.50
Necroptosis	activates	pathway	0.50
Neuron	activates	cell_type	0.50
White Matter	activates	process	0.50
MOTOR NEURON	activates	concept	0.50
disease	causes	disease	0.50
MITOCHONDRIA	regulates	cell_type	0.50
Astrocytes	regulates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
MITOCHONDRIA	activates	cell_type	0.50
apoptosis	activates	process	0.50
Ulcerative Colitis	activates	disease	0.50
Autophagy	protects_against	process	0.50
TUMOR	protects_against	disease	0.50
Cardiovascular	protects_against	disease	0.50
disease	protects_against	disease	0.50
CELL DEATH	activates	concept	0.50
Neuroinflammatory	regulates	pathway	0.50
FLAVONOIDS	regulates	concept	0.50
GLUCOSE METABOLISM	regulates	concept	0.50
Neurodegeneration	inhibits	disease	0.50
SCHIZOPHRENIA	inhibits	disease	0.50
TUMOR	regulates	disease	0.50
ISCHEMIA	inhibits	disease	0.50
NEURONS	inhibits	concept	0.50
SNARE	inhibits	protein	0.50
aging	activates	phenotype	0.50
White Matter	expressed_in	process	0.50
mTOR	inhibits	entity	0.50
VAMP8	inhibits	gene	0.50
MIRO1	regulates	protein	0.50
MIRO1	interacts_with	protein	0.50
PARKIN	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
Tumor Microenvironment	activates	process	0.50

Incoming (9)

Source	Relation	Type	Str
AUTISM	inhibits	entity	0.60
EPILEPSY	inhibits	entity	0.60
DEPRESSION	associated_with	entity	0.60
ALS	activates	entity	0.60
AUTISM	inhibits	disease	0.50
EPILEPSY	inhibits	gene	0.50
PHAGOCYTOSIS	regulates	gene	0.50
DEPRESSION	associated_with	disease	0.50
Neuroinflammation	interacts_with	process	0.50

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE ε4-driven microglial lipid handling as proximal driver	0.626	neurodegeneration	Non-Neuronal Transcriptional Changes Pre
Physiological SCFAs may worsen alpha-synuclein pathology thr	0.550	neurodegeneration	Do physiological concentrations of SCFAs
ABCA7-TREM2 Co-Targeting for Microglial Lipid Handling	0.538	neurodegeneration	Why does the V1613M variant reduce amylo
Reactive astrocyte glutamate-handling failure sustains dendr	0.490	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (1)

Scientific analyses that reference this entity

Ferroptosis in ALS motor neuron vulnerability

neurodegeneration | 2026-04-26 | 3 hypotheses Top: 0.745

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the role of GPX4-dependent ferroptosis, lipid peroxidation, and iron han

closed · Rounds: 4 · Score: 0.78 · 2026-04-26

Related Research

Hypotheses and analyses mentioning hand in their description or question text

No additional research found