Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HCN |
| Key Genes/Proteins | HCN1, HCN2, HCN4 |
| Related Diseases | Atrioventricular Block, delta/theta band frequency sensitivity, epilepsy, intrinsic membrane properties |
| Related Pathways | autophagy pathway, CRISPR-Cas |
| Linked Hypotheses | 3 hypotheses |
Knowledge base pages for this entity
graph TD
HCN[HCN]
HCN -->|expressed in| Heart[Heart]
HCN -->|expressed in| Central_Nervous_System[Central Nervous System]
HCN -->|expressed in| Peripheral_Nervous_System[Peripheral Nervous System]
HCN -->|regulates| Cardiac_discharge_activity[Cardiac discharge activity]
HCN -->|regulates| Neuronal_discharge_activity[Neuronal discharge activity]
HCN -->|mediates| hyperpolarization[hyperpolarization]
HCN -->|mediates| Ih_Current[Ih Current]
HCN -->|mediates| intrinsic_membrane_properties[intrinsic membrane properties]
HCN -->|modulates| delta_theta_band_frequency_sen[delta/theta band frequency sensitivity]
HCN -->|regulates| synaptic_input_processing[synaptic input processing]
macaque_supragranular_pyramida[macaque supragranular pyramidal neurons] -->|interacts| HCN| Target | Relation | Type | Str |
|---|---|---|---|
| Heart | expressed_in | cell_type | 0.95 |
| Peripheral Nervous System | expressed_in | cell_type | 0.95 |
| Central Nervous System | expressed_in | cell_type | 0.95 |
| Cardiac discharge activity | regulates | process | 0.94 |
| Neuronal discharge activity | regulates | process | 0.93 |
| hyperpolarization | mediates | process | 0.92 |
| Ih Current | mediates | process | 0.90 |
| intrinsic membrane properties | mediates | phenotype | 0.90 |
| delta/theta band frequency sensitivity | modulates | phenotype | 0.85 |
| Ventricular Tachycardia | associated_with | disease | 0.82 |
| NEURON | expressed_in | cell_type | 0.80 |
| Atrioventricular Block | associated_with | disease | 0.80 |
| synaptic input processing | regulates | process | 0.80 |
| Neuropathic Pain | contributes_to | disease | 0.75 |
| HCN1 | activates | gene | 0.70 |
| epilepsy | activates | disease | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| epilepsy | regulates | disease | 0.60 |
| HCN1 | inhibits | gene | 0.60 |
| HCN2 | inhibits | gene | 0.60 |
| HCN4 | inhibits | gene | 0.60 |
| HCN2 | implicated_in | gene | 0.60 |
| HCN4 | implicated_in | gene | 0.60 |
| neurodegeneration | interacts_with | disease | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| HCN1 | regulates | gene | 0.60 |
| CRISPR-Cas | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| macaque supragranular pyramidal neurons | interacts_with | cell_type | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HCN1-Mediated Resonance Frequency Stabilization Therapy | 0.648 | neurodegeneration | Selective vulnerability of entorhinal co |
| Closed-loop tACS targeting EC-II somatostatin interneurons t | 0.564 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting | 0.526 | synaptic biology | How do P/Q channel deficits paradoxicall |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.509 | 0.50 | human postmortem brain tissue | proposed | $520,000 |
| s:** - Test whether HCN1 knockout specifically in EC layer II accelera | falsification | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| tACS Connectivity Trial in Early Alzheimer's | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $730,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Levodopa Response Determinants in PSP — Biomarker-Guided Prediction St | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Neural Oscillation Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| HCN channels reveal conserved and divergent physiology in supragranular pyramida [PMID:40894563] | ["Radaelli C", "Schmitz M", "Liu X", "Sa | bioRxiv (Cold Spring Harbor La | 2025 | 1 |
| Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. [PMID:39085604] | Kim ED, Wu X, Lee S, Tibbs GR, Cunningha | Nature | 2024 | 1 |
| The Impact of Altered HCN1 Expression on Brain Function and Its Relationship wit [PMID:37366350] | Zhao K, Li Y, Yang X, Zhou L | Curr Neuropharmacol | 2023 | 1 |
| HCN channels and absence seizures. [PMID:37001612] | Crunelli V, David F, Morais TP, Lorincz | Neurobiol Dis | 2023 | 1 |
| Cardiac and neuronal HCN channelopathies. [PMID:32424620] | Rivolta I, Binda A, Masi A, DiFrancesco | Pflugers Arch | 2020 | 1 |
| HCN1 channels significantly shape retinal photoresponses. [PMID:22183410] | Tanimoto N, Brombas A, Müller F, Seelige | Adv Exp Med Biol | 2012 | 1 |
| HCN channels reveal conserved and divergent physiology in supragranular pyramida [PMID:41559478] | ["Radaelli C", "Schmitz M", "Liu X", "Sa | Communications biology | 2026 | 0 |
| Comprehensive classification of HCN1 variants linked to neurodevelopmental disor [PMID:41890092] | ["Castelli R", "Marini C", "Porro A", "C | bioRxiv : the preprint server | 2026 | 0 |
| Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-base [PMID:41876451] | ["Levi G", "Sintov A", "Zohar J", "Todde | Translational psychiatry | 2026 | 0 |
| Subthreshold Kir and I [PMID:41689161] | ["Moreno C", "Riquelme D", "Cornejo C", | Biological research | 2026 | 0 |
| Gene expression of the HCN family in rats with pilocarpine-induced epilepsy and [PMID:41903877] | ["Dos Santos R", "Dos Santos M", "da Cos | Brain research | 2026 | 0 |
| Effects of post-stress corticosterone on hippocampal excitability and behavior i [PMID:41654499] | ["Kim C", "Kim J", "Michael S"] | Translational psychiatry | 2026 | 0 |
| Atenolol rescues premature mortality in genetic mouse models of sudden unexpecte [PMID:40991209] | ["Soh M", "Hu A", "Kuanyshbek A", "Moham | Epilepsia | 2026 | 0 |
| Do Subsets of Widefield Vertical Cells Exist in the Mouse Superior Colliculus? [PMID:41846482] | ["Naeem N", "Slusarczyk A", "Bickford M" | The Journal of comparative neu | 2026 | 0 |
| Hyperpolarization-activated cation channels confer tonotopic specialization for [PMID:41822824] | ["Owusu-Nyantakyi K", "Hamlette L", "Ash | bioRxiv : the preprint server | 2025 | 0 |
| Multilayered genetic dissection of autism: insights from whole-exome sequencing, [PMID:41420732] | ["Eser M", "Hekimoglu G", "Kutlubay B"] | Neurogenetics | 2025 | 0 |
| Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid [PMID:40504482] | ["Saini A", "Sharma S", "Rana P", "Khann | Molecular neurobiology | 2025 | 0 |
| Genetic Etiology of Developmental and Epileptic Encephalopathy in a Turkish Coho [PMID:41153369] | ["Sunnetci-Akkoyunlu D", "Kara B", "Ozer | Genes | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Identifying sex similarities and differences in structure and function of the si [PMID:39703520] | Yin Z, Torre E, Marrot M, Peters CH, Fea | Frontiers in medicine | 2024 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning HCN in their description or question text
No additional research found