Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CRISPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
No AI portrait yet
| Name | CRISPR |
| Key Genes/Proteins | Cell-type-specific essential genes, Disease-causing mutations with integrated reporters, NURR1, PITX3, neuronal identity transcription factors, PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes |
| Related Diseases | Amyotrophic Lateral Sclerosis |
| Linked Hypotheses | 12 hypotheses |
Knowledge base pages for this entity
graph TD
CRISPR[CRISPR]
CRISPR -->|targets| Central_Nervous_System[Central Nervous System]
CRISPR -->|mediates| Epigenetic_Modifications[Epigenetic Modifications]
CRISPR -->|targets| APOE[APOE]
CRISPR -->|promotes| Metabolic_Reprogramming[Metabolic Reprogramming]
CRISPR -->|edits| Mitochondrial_Genome[Mitochondrial Genome]
CRISPR -->|targets| Adult_Neurons[Adult Neurons]
CRISPR -->|activates| Misfolded_Protein_Aggregates[Misfolded Protein Aggregates]
CRISPR -->|inhibits| MSH3[MSH3]
CRISPR -->|inhibits| PMS1[PMS1]
CRISPR -->|treats| Amyotrophic_Lateral_Sclerosis[Amyotrophic Lateral Sclerosis]
SDA_2026_04_02_gap_crispr_neur[SDA-2026-04-02-gap-crispr-neurodegeneration-20260402] -->|investigates| CRISPR
Viral_Vector[Viral Vector] -->|mediates| CRISPR
exosome[exosome] -->|interacts| CRISPR
blood_brain_barrier[blood brain barrier] -->|inhibits| CRISPR
Cell_type_specific_essential_g[Cell-type-specific essential genes] -->|co_associated_with| CRISPR
PGC1A__SIRT1__FOXO3__mitochond[PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes] -->|co_associated_with| CRISPR
NURR1__PITX3__neuronal_identit[NURR1, PITX3, neuronal identity transcription factors] -->|co_associated_with| CRISPR
Disease_causing_mutations_with[Disease-causing mutations with integrated reporters] -->|co_associated_with| CRISPR| Target | Relation | Type | Str |
|---|---|---|---|
| Epigenetic Modifications | mediates | process | 0.95 |
| Central Nervous System | targets | brain_region | 0.95 |
| APOE | targets | gene | 0.90 |
| Metabolic Reprogramming | promotes | process | 0.90 |
| Adult Neurons | targets | cell_type | 0.85 |
| Alzheimer's Disease | treats | disease | 0.70 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 | investigates | analysis | 0.95 |
| exosome | interacts_with | compound | 0.85 |
| Viral Vector | mediates | compound | 0.85 |
| blood brain barrier | inhibits | brain_region | 0.80 |
| Disease-causing mutations with integrated reporters | co_associated_with | gene | 0.30 |
| Cell-type-specific essential genes | co_associated_with | gene | 0.30 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | co_associated_with | gene | 0.30 |
| NURR1, PITX3, neuronal identity transcription factors | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
gene therapy | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803
neurodegeneration | 2026-04-02 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Acteoside treatment in LPS-induced SALI mouse model | validation | sepsis-associated acute lung i | 0.900 | 0.00 | LPS-induced SALI mouse model | proposed | N/A |
| Nrf2 inhibitor ML385 mechanism validation experiment | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells and/or mouse mo | proposed | N/A |
| Acteoside effects on RAW264.7 macrophage cells | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells | proposed | N/A |
| CRISPR Gene Correction Approaches for CBS/PSP | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| Exploring Parkinson's through the Lens of Genomics and Bioinformatics. [PMID:39929729] | Menon V | Cold Spring Harb Perspect Med | 2026 | 0 |
| Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604] | Casazza KM, Williams GM, Johengen L, Kel | bioRxiv | 2026 | 0 |
| A Simple Method for RNA-Seq of Manually Isolated Chromatophores in Oryzias Fishe [PMID:41805030] | Goda M, Miyagi A, Sugiwaka K, Watanabe M | Dev Growth Differ | 2026 | 0 |
| Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associate [PMID:41576950] | ["Ghoochani A", "Heiby J", "Rawat E", "M | Cell | 2026 | 0 |
| Decoding Alzheimer's genetic risk through intercellular communication in the hum [PMID:41707523] | Lish AM, Young-Pearse TL | Current opinion in neurobiolog | 2026 | 0 |
| Neuromodulatory role and therapeutic potential of N 6 -methyladenosine RNA methy [PMID:40618260] | Zhang J, Ma W, Liu R, Li X, Yuan Z, Chen | Neural regeneration research | 2026 | 0 |
| Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Progr [PMID:41676679] | Xie Y, Chang L, Zhong G, Rink JA, Báez-B | bioRxiv : the preprint server | 2026 | 0 |
| Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the [PMID:41743852] | Zhang Y, Guo X, Wang Q, Xiao L, Liu Q, G | Research (Washington, D.C.) | 2026 | 0 |
| Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disea [PMID:39824182] | ["Handsaker R", "Kashin S", "Reed N", "T | Cell | 2025 | 0 |
| Canagliflozin attenuates neurodegeneration and ameliorates dyskinesia through ta [PMID:39700958] | ["Abdelaziz A", "Rasheed N", "Zaki H", " | International immunopharmacolo | 2025 | 0 |
| Metabolic rewiring prevents neurodegeneration caused by chronic mitochondrial dy [PMID:41151583] | Richhariya S, Shin D, Schlichting M, Ros | Current biology : CB | 2025 | 0 |
| HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associatio [PMID:41037108] | Díaz-Belloso R, Martín-Bornez M, Macías- | Journal of neurology | 2025 | 0 |
| Nurr1 modulators - a patent review (2019-present). [PMID:40481732] | ["Egner M", "Merk D"] | Expert opinion on therapeutic | 2025 | 0 |
| VDAC2 loss elicits tumour destruction and inflammation for cancer therapy. [PMID:40108474] | Yuan S, Sun R, Shi H, Chapman NM, Hu H, | Nature | 2025 | 0 |
| Focused ultrasound widely broadens AAV-delivered Cas9 distribution and activity. [PMID:39893321] | Gumusgoz E, Kasiri S, Youssef I, Verma M | Gene therapy | 2025 | 0 |
| Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associate [PMID:39464040] | ["Ghoochani A", "Heiby J", "Rawat E", "M | bioRxiv : the preprint server | 2024 | 0 |
| 25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain [PMID:39181516] | Loiola RA, Nguyen C, Dib S, Saint-Pol J, | Biochimica et biophysica acta. | 2024 | 0 |
| Cholinergic neurodegeneration and cholesterol metabolism dysregulation by consti [PMID:37900943] | ["Comaposada-Bar\u00f3 R", "Benito-Mart\ | Frontiers in molecular neurosc | 2023 | 0 |
| The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegenerati [PMID:37990334] | ["Li T", "Tan X", "Tian L", "Jia C", "Ch | Journal of neuroinflammation | 2023 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.71 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.90 · 2026-04-02