gut

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.699

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.682

What brain concentrations of SCFAs are achieved via oral probiotics and are they

pharmacokinetics | 2026-04-11 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 1 hypotheses Top: 0.380

Gut-Brain Axis Therapeutics for AD

neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.525

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 0 hypotheses

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.907

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.653

Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysreg

closed · Rounds: 4 · Score: 0.13 · 2026-04-27

Hypothesis debate: Microbial Inflammasome Priming Prevention

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

closed · Rounds: 4 · Score: 0.76 · 2026-04-26

Formal debate: TLR4 priming is the actionable driver in: How does gut microbiome

closed · Rounds: 3 · Score: 0.75 · 2026-04-26

Formal debate: plasma LPS-binding protein separates causal from compensatory sta

closed · Rounds: 3 · Score: 0.75 · 2026-04-26

How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegen

closed · Rounds: 4 · Score: 0.78 · 2026-04-26

Hypothesis debate: SCFA Deficiency Disrupts Microglial Homeostasis and Promotes

closed · Rounds: 4 · Score: 0.60 · 2026-04-26

Hypothesis debate: Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propag

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: Enteric Nervous System Dysfunction as Self-Reinforcing Pathol

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Hypothesis debate: LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Com

Score: 0.669 · neurodegeneration · 2026-04-02

## Mechanistic Overview Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain Anti-Inflammatory Communication start

Physiological SCFAs may reduce alpha-synuclein burden primarily through a gut-fi

Score: 0.650 · neurodegeneration · 2026-04-24

Low-micromolar systemic SCFA exposure is unlikely to directly drive substantia nigra alpha-synuclein clearance, but colo

Gut-Brain Axis M-Cell Modulation

Score: 0.629 · unknown disease · 2026-04-04

## Mechanistic Overview Gut-Brain Axis M-Cell Modulation starts from the claim that modulating GP2, SPIB within the dise

H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier R

Score: 0.620 · neurodegeneration · 2026-04-15

## Mechanistic Overview H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration start

Correcting Gut Microbial Dopamine Imbalance to Support Systemic Dopaminergic Fun

Score: 0.606 · neurodegeneration · 2026-04-02

## Mechanistic Overview Correcting Gut Microbial Dopamine Imbalance to Support Systemic Dopaminergic Function starts fro

Gut Bacterial Metabolite-AhR Dysregulation Converts SCFA-Deficiency into IDO1-Dr

Score: 0.580 · neurodegeneration · 2026-04-26

Aryl hydrocarbon receptor (AhR), expressed in microglia, astrocytes, and neurons, normally ligates tryptophan catabolite

Gut-Brain Axis Microbiome Modulation

Score: 0.557 · Alzheimer's disease · 2026-04-04

# Gut-Brain Axis Microbiome Modulation: Preventing Neurodegeneration Through GPR43/GPR109A Signaling ## Scientific Ba

TLR2 Recognition of Gut-Derived Fungal and Bacterial D-Alanylated Lipoteichoic A

Score: 0.550 · neurodegeneration · 2026-04-26

Dysbiosis permits overgrowth of SIBO species and opportunistic fungi (Candida albicans, Malassezia) whose cell wall comp

Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fungal Amyloid Synergi

Score: 0.540 · neurodegeneration · 2026-04-26

Commensal bacteria (E. coli, Salmonella) produce curli amyloid fibers encoded by the csg operon, while Candida and Sacch

Gut Barrier Permeability-α-Synuclein Axis Modulation

Score: 0.533 · neurodegeneration · 2026-04-02

Dysbiotic bacteria compromise intestinal barrier integrity through zonulin pathway activation, allowing bacterial antige

Gut-derived butyrate reprograms microglia for amyloid clearance via HDAC2 inhibi

Score: 0.525 · Alzheimer's disease · 2026-04-26

Specific butyrate-producing gut bacteria (e.g., Faecalibacterium, Roseburia) generate systemic butyrate that crosses the

Gut dysbiosis-driven monocyte reprogramming toward NETotic phenotype accelerates

Score: 0.380 · Alzheimer's disease · 2026-04-27

Intestinal barrier dysfunction and LPS translocation primes CCR2+ circulating monocytes and neutrophils toward a NETosis

Gut butyrate deficiency impairs microglial amyloid clearance via HDAC2-mediated

Score: 0.380 · Alzheimer's disease · 2026-04-27

Gut dysbiosis in Alzheimer's disease reduces butyrate-producing bacteria (Faecalibacterium prausnitzii, Roseburia intest

plasma LPS-binding protein separates causal from compensatory states in: How doe

Score: 0.346 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on plasma LPS-binding protein can distinguish harmful mechanisms from protective

TLR4 priming is the actionable driver in: How does gut microbiome dysbiosis cont

Score: 0.343 · neurodegeneration · 2026-04-26

The gap can be tested by treating TLR4 priming as an upstream driver rather than a passive correlate. If true, perturbin