concept

CRBN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRBN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

27Outgoing

11Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CRBN
Key Genes/Proteins	Actin, AND, ATP, CANCER, CDK4, DNA
Related Diseases	Als, ALS, Cancer, Encephalitis
Related Pathways	apoptosis pathway

Pathway Diagram

graph TD
    CRBN["CRBN"]
    CRBN -->|"regulates"| protein_degradation["protein degradation"]
    CRBN -->|"ubiquitinates"| IKZF1["IKZF1"]
    CRBN -->|"ubiquitinates"| IKZF3["IKZF3"]
    CRBN -->|"interacts"| UBIQUITIN["UBIQUITIN"]
    CRBN -->|"target for"| Cancer["Cancer"]
    CRBN -->|"target for"| Als["Als"]
    CRBN -->|"activates"| Senescence["Senescence"]
    thalidomide_analogs["thalidomide analogs"] -->|"binds_to"| CRBN
    CRL4["CRL4"] -->|"component_of"| CRBN
    AND["AND"] -->|"activates"| CRBN
    CDK4["CDK4"] -->|"activates"| CRBN
    RB1["RB1"] -->|"inhibits"| CRBN
    UBIQUITIN -->|"interacts"| CRBN
    DNAJB6["DNAJB6"] -->|"interacts"| CRBN
    RNA["RNA"] -->|"interacts"| CRBN

Outgoing (27)

Target	Relation	Type	Str
protein degradation	regulates	process	0.95
IKZF3	ubiquitinates	protein	0.90
IKZF1	ubiquitinates	protein	0.90
UBIQUITIN	interacts_with	protein	0.85
ubiquitin-proteasome	participates_in	pathway	0.80
Senescence	activates	disease	0.65
ALS	interacts_with	disease	0.65
Encephalitis	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
DNAJB6	interacts_with	gene	0.60
Actin	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
DYRK1A	activates	gene	0.60
DYRK1B	activates	gene	0.60
senescence	participates_in	pathway	0.60
DNA	activates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
CANCER	therapeutic_target	gene	0.60
XPO1	activates	gene	0.60
UBE2N	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
PPP2CB	interacts_with	gene	0.60
MDM2	interacts_with	gene	0.55
VHL	interacts_with	gene	0.55

Incoming (11)

Source	Relation	Type	Str
thalidomide analogs	binds_to	drug	0.95
CRL4	component_of	entity	0.90
RNA	interacts_with	gene	0.60
PPP2CB	interacts_with	gene	0.60
UBE2N	interacts_with	gene	0.60
ATP	activates	gene	0.60
AND	activates	gene	0.60
CDK4	activates	gene	0.60
RB1	inhibits	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
DNAJB6	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CRBN in their description or question text

No additional research found