| Gene Symbol | TIRAP |
| Full Name | TIR Domain-Containing Adaptor Protein |
| Chromosome | 11p15.5 |
| Protein Type | Adaptor Protein |
| Function | is a critical signaling adaptor protein that mediates Toll-like receptor (TLR) signaling in the innate immune system. |
| Primary Expression | microglia, astrocytes, and neurons, where it contributes to neuroinflammator |
| Molecular Weight | 28 kDa |
| Amino Acids | 235 aa |
| Exons | 6 |
| Pathways | Immune Response |
| NCBI Gene ID | 114609 |
| Ensembl ID | ENSG00000150459 |
| GeneCards | TIRAP |
| Human Protein Atlas | TIRAP |
| N-terminal domain | Contains a phosphatidylinositol 4,5-bisphosphate (PIP2)-binding motif that enables membrane localization |
| Associated Diseases | ALS, Encephalitis, Inflammation, Multiple Sclerosis, neurodegeneration |
| Interactions | AND, CD14, MyD88, MYD88, NF-ΚB, TLR |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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