gene

PRKCG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKCG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

26Outgoing

7Incoming

0Experiments

0Debates

Summary

PRKCG is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, expressed in. Associated with Ataxia, Neurodegeneration, Spinocerebellar Ataxia. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PRKCG
Full Name	Protein Kinase C Gamma
Chromosome	19q13.42
Function	is a key mediator of the diacylglycerol (DAG) signaling pathway.
Primary Expression	Neuron-specific
Molecular Weight	89 kDa
Amino Acids	697 aa
Exons	17
UniProt ID	[P05129](https://www.uniprot.org/uniprot/P05129)
Ensembl ID	ENSG00000156508
OMIM	176980
GeneCards	PRKCG
Human Protein Atlas	PRKCG
Associated Diseases	Ataxia, Neurodegeneration, Spinocerebellar Ataxia
Interactions	ERK1
KG Connections	33 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PRKCG — Protein Kinase C Gamma

gene · 2761 words

→

PRKCG Protein (PKCγ)

protein · 809 words

→

Pathway Diagram

graph TD
    PRKCG["PRKCG"]
    Neurodegeneration{"Neurodegeneration"}
    PRKCG -->|"associated with"| Neurodegeneration
    Ataxia{"Ataxia"}
    PRKCG -->|"associated with"| Ataxia
    PRKCG -->|"regulates"| Neurodegeneration
    Spinocerebellar_Ataxia{"Spinocerebellar Ataxia"}
    PRKCG -->|"causes"| Spinocerebellar_Ataxia
    PRKCG -->|"causes"| Neurodegeneration
    PKC["PKC"]
    PRKCG -->|"associated with"| PKC
    NEURODEGENERATION["NEURODEGENERATION"]
    PRKCG -->|"causes"| NEURODEGENERATION
    GENES["GENES"]
    PRKCG -->|"causes"| GENES
    AND["AND"]
    PRKCG -->|"associated with"| AND
    Purkinje_Cell["Purkinje Cell"]
    PRKCG -->|"expressed in"| Purkinje_Cell
    Neuron["Neuron"]
    PRKCG -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    PRKCG -->|"implicated in"| neurodegeneration
    PKC -->|"associated with"| PRKCG
    GENES -->|"associated with"| PRKCG
    style PRKCG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
Fragile X-Associated Tremor/Ataxia Syndrome	therapeutic_target	disease	0.90
Fragile X-Associated Tremor/Ataxia Syndrome	modulates	disease	0.90
Gabaergic Dysfunction	associated_with	process	0.85
Cgg-Associated Neurotoxicity	modulates	mechanism	0.85
Fragile X-associated tremor/ataxia syndrome	modulates	disease	0.85
neurodegeneration	contributes_to	process	0.80
therapeutic_target	targets	process	0.80
disease onset	promotes	phenotype	0.80
Gabaergic Neurons	expressed_in	cell_type	0.80
Spinocerebellar Ataxia	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Purkinje	associated_with	cell_type	0.60
PKC	associated_with	gene	0.60
Rb	associated_with	protein	0.60
App	associated_with	protein	0.60
Neuron	associated_with	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
NEURODEGENERATION	causes	gene	0.60
GENES	causes	gene	0.60
Neuron	expressed_in	cell_type	0.55
Purkinje Cell	expressed_in	cell_type	0.55
microglia	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
GENES	causes	gene	0.60
PKC	associated_with	gene	0.60
ERK	regulates	gene	0.60
GENES	associated_with	gene	0.60
PKC	encodes	gene	0.60
ERK1	activates	gene	0.60
MAPT	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRKCG in their description or question text

No additional research found