Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SHIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K pathway | modulates | pathway | 0.60 |
| TREM2 | regulates | gene | 0.60 |
| leukemogenesis | involved_in | biological_process | 0.60 |
| therapeutic_target | therapeutic_target | concept | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INPP5D | co_associated_with | gene | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| INPP5D (SHIP1) Inhibition to Shift Microglial Polarization | 0.758 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.941
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850] | Xu Z, Chen M, Liang F, Song S, Lei J et | J Transl Med | 2026 | 0 |
| Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359] | Xie X, Liu J, Liang W, Zhang Y, Gong X e | Immunity | 2026 | 0 |
| INPP5D/SHIP1-mediated immunometabolic remodeling of renal monocytes in idiopathi [PMID:41853261] | Dai H, Liu B, Rui H, Yang L, Jiang H et | Front Immunol | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Mol Neurodegener | 2026 | 0 |
| SHIP-1 adapter functions mediate recruitment of FCRL1 to the BCR and inhibition [PMID:41968726] | Wolfe MM, Tallon Arranz R, Zenni EL, Wil | Immunohorizons | 2026 | 0 |
| Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammat [PMID:41633359] | Xie X, Liu J, Liang W, Zhang Y, Gong X, | Immunity | 2026 | 0 |
| Single-cell sequencing analysis and machine learning model reveal aberrant TIM-3 [PMID:41580850] | Xu Z, Chen M, Liang F, Song S, Lei J, Hu | Journal of translational medic | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.57 · 2026-04-01
Hypotheses and analyses mentioning SHIP1 in their description or question text
No additional research found