| Gene Symbol | TCF7L2 |
| Aliases | Transcription Factor 7-Like 2 |
| Protein Type | Transcription Factor |
| Function | TCF7L2 serves multiple physiological functions |
| Pathways | Wnt, wnt, Wnt signaling, Wnt Signaling |
| UniProt ID | Q9NQB0](https://www.uniprot.org/uniprot/Q9NQB0) |
| NCBI Gene ID | 6934 |
| GeneCards | TCF7L2 |
| Human Protein Atlas | TCF7L2 |
| β-catenin binding domain | N-terminal region for interaction with β-catenin |
| HMG box | DNA-binding domain recognizing Wnt-responsive elements (WRE) |
| C-clamp | Additional DNA-binding domain enhancing specificity |
| Repression domains | Bind Groucho/TLE co-repressors in absence of Wnt signaling[@cadigan2012] |
| Associated Diseases | Als, Diabetes, Type 2 Diabetes, Type 2 Diabetes Mellitus |
| Interactions | APOA2, CANCER, FOXO3, GENES, IL1R1, IL-6 |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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