concept

COGNITIVE IMPAIRMENT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COGNITIVE IMPAIRMENT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

386Connections

0Hypotheses

5Analyses

30Outgoing

50Incoming

0Experiments

5Debates

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💡 Concept Info

Name	COGNITIVE IMPAIRMENT
Key Genes/Proteins	AQP4

Pathway Diagram

graph TD
    COGNITIVE_IMPAIRMENT["COGNITIVE IMPAIRMENT"]
    Trilobatin["Trilobatin"] -->|"treats"| COGNITIVE_IMPAIRMENT
    Tmt["Tmt"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Ckd["Ckd"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Kidney_Failure["Kidney Failure"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Alzheimer_s_Disease["Alzheimer's Disease"] -->|"causes"| COGNITIVE_IMPAIRMENT
    Rehmannioside_A["Rehmannioside A"] -->|"treats"| COGNITIVE_IMPAIRMENT
    Protective_Genetic_Variants["Protective Genetic Variants"] -->|"modulates"| COGNITIVE_IMPAIRMENT
    Metformin["Metformin"] -.protects against.-> COGNITIVE_IMPAIRMENT
    Neuroinflammation["Neuroinflammation"] -->|"causes"| COGNITIVE_IMPAIRMENT
    MNPs_FMN["MNPs@FMN"] -->|"treats"| COGNITIVE_IMPAIRMENT

Outgoing (30)

Target	Relation	Type	Str
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer's Disease	biomarker_for	disease	0.90
Narcolepsy Type 1	associated_with	disease	0.90
Alzheimer Disease	associated_with	disease	0.85
Diabetic Encephalopathy	associated_with	disease	0.85
Neuroprotection	activates	process	0.50
Gut Microbiota	inhibits	process	0.50
PI3K/AKT PATHWAY	activates	concept	0.50
ENDOTHELIAL CELLS	inhibits	concept	0.50
PI3K/AKT SIGNALING	activates	concept	0.50
Cognitive Decline	inhibits	disease	0.50
NEUTROPHIL	inhibits	cell_type	0.50
NEUTROPHILS	inhibits	concept	0.50
MICROGLIAL ACTIVATION	activates	concept	0.50
Gut Microbiota	activates	process	0.50
EXCITOTOXICITY	activates	concept	0.50
AMYLOID-β	activates	concept	0.50
Cellular Senescence	inhibits	cell_type	0.50
WNT SIGNALING	inhibits	concept	0.50
CEREBRAL CORTEX	inhibits	concept	0.50
MAPK SIGNALING	inhibits	concept	0.50
CEREBROSPINAL FLUID	inhibits	concept	0.50
CX43	inhibits	concept	0.50
PREFRONTAL CORTEX	inhibits	concept	0.50
GENE EXPRESSION	inhibits	concept	0.50
AMYLOID-β	inhibits	concept	0.50
CEREBROSPINAL FLUID	activates	concept	0.50
CHOLESTEROL METABOLISM	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
NUCLEUS	inhibits	concept	0.50

Incoming (356)

Source	Relation	Type	Str
Chronic Kidney Disease	causes	disease	0.95
Metformin	treats	drug	0.95
HSP70	associated_with	protein	0.95
Tmt	causes	compound	0.95
Ginsenoside Ro	treats	compound	0.95
Stem Cell Therapy	treats	drug	0.95
ALZHEIMER'S DISEASE	causes	disease	0.95
Copper	causes	compound	0.95
Danggui-Shaoyao-San	treats	drug	0.95
BDNF	associated_with	protein	0.95
p-tau217	correlates_with	biomarker	0.95
Ginsenoside Re	treats	compound	0.95
Ginsenoside Rk1	treats	compound	0.95
Quinolinic Acid	causes	compound	0.95
Trilobatin	treats	compound	0.95
Pterostilbene	treats	compound	0.95
Scopolamine	causes	drug	0.95
Ckd	causes	disease	0.95
Kidney Failure	causes	disease	0.95
Parkinson's Disease	causes	disease	0.95
Alzheimer's Disease	causes	disease	0.95
Butyrate	treats	compound	0.95
Parkinson Disease	causes	disease	0.92
Gut-Brain Axis	regulates	pathway	0.90
Neutrophil-Microglia Interactions	mediates	process	0.90
AQP4	causes	protein	0.90
Chronic REM sleep deprivation	causes	process	0.90
sleep deprivation	causes	mechanism	0.90
TDP43	contributes_to	entity	0.90
Rehmannioside A	treats	drug	0.90
Synaptic Plasticity	associated_with	process	0.90
C3A	correlates_with	protein	0.90
Millimeter waves	treats	compound	0.90
29328926	increased with	paper	0.90
Gut-Brain Axis	modulates	pathway	0.90
Plasma GFAP	correlates_with	biomarker	0.90
Neuroinflammation	causes	process	0.90
MNPs@FMN	treats	drug	0.90
SYN1	associated_with	protein	0.90
P-Tau217	correlates_with	biomarker	0.90
Tdp-43 Pathology	associated_with	biomarker	0.90
LARS2	associated_with	gene	0.90
Sulfatide Deficiency	causes	phenotype	0.90
Tanshinone Iia	protects_against	compound	0.90
Protective Genetic Variants	protects_against	biomarker	0.90
Exendin-4	treats	drug	0.90
APOE ε4	causes	gene	0.90
Aging	associated_with	process	0.90
Metformin	protects_against	drug	0.90
APP/PS1	causes	gene	0.90