Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Major Depression: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Psychosocial Functioning | causes | phenotype | 0.95 |
| Quality of Life | associated_with | phenotype | 0.95 |
| Disease Burden | contributes_to | process | 0.85 |
| Clinical Detection | associated_with | process | 0.80 |
| Treatment Response Variability | mediates | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| lipopolysaccharide | causes | compound | 0.90 |
| C1Q/C3-CR3 signaling pathway | implicated_in | pathway | 0.90 |
| HPA-axis | associated_with | pathway | 0.90 |
| synaptic loss | contributes_to | phenotype | 0.85 |
| Epa | treats | compound | 0.80 |
| Dha | treats | compound | 0.80 |
| HPT-axis | associated_with | pathway | 0.80 |
| BDNF | associated_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Major Depression in their description or question text
No additional research found