protein 1,138 words KG: RAD18PROTEIN
Contents

RAD18 Protein — DNA Damage Repair and Translesion Synthesis

🔬 Protein Info
Gene SymbolRAD18
Full NameRAD18 E3 Ubiquitin Protein Ligase
AliasesRAD18PROTEIN
Chromosome9q31.1
Protein TypeLigase
Functionis a key DNA damage response protein that plays a critical role in maintaining genome stability through translesion DNA synthesis (TLS).
PathwaysDNA Damage Response
UniProt ID[Q9NS91](https://www.uniprot.org/uniprotkb/Q9NS91/entry)
GeneCardsRAD18
Human Protein AtlasRAD18
Associated DiseasesAls
InteractionsActin, AND, BRCA1, DNA, GBM, GLIOBLASTOMA
KG Connections56 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (14)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Lysosomal Membrane Repair Enhancement
Score: 0.54
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
PARP1 Inhibition Therapy
Score: 0.74

Related Analyses (11)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (2)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (15)

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clinical · Pages share 6 hypotheses
DALY Methodology — Neurodegeneration
disease · Pages share 6 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 6 hypotheses
BEACoN Study - Biomarker Exploration in Aging, Cognitio
clinical · Pages share 6 hypotheses
Swedish BioFINDER 2 Study: Biomarkers and Neurodegenera
clinical · Pages share 6 hypotheses

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