| Gene Symbol | RAD18 |
| Full Name | RAD18 E3 Ubiquitin Protein Ligase |
| Chromosome | 9q31.1 |
| Protein Type | Ligase |
| Function | is a key DNA damage response protein that plays a critical role in maintaining genome stability through translesion DNA synthesis (TLS). |
| Pathways | DNA Damage Response |
| UniProt ID | [Q9NS91](https://www.uniprot.org/uniprotkb/Q9NS91/entry) |
| GeneCards | RAD18 |
| Human Protein Atlas | RAD18 |
| RING finger domain | A C3HC4-type RING finger motif that facilitates E3 ubiquitin ligase activity[@takizawa2010] |
| UBZ domain | A ubiquitin-binding zinc finger domain that recognizes ubiquitinated PCNA |
| RAD6 interaction domain | Region required for binding to RAD6A/B ubiquitin-conjugating enzymes |
| PCNA-binding domain | motif for direct interaction with PCNA at replication forks |
| Associated Diseases | Als |
| Interactions | Actin, AND, BRCA1, DNA, GBM, GLIOBLASTOMA |
| KG Connections | 56 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!