| Gene Symbol | PSMA1 |
| Full Name | Proteasome 20S Subunit Alpha 1 |
| Aliases | PSMA1PROTEIN |
| Chromosome | 11p15.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | ** | Cytoplasm, Nucleus | |
| Molecular Weight | 27.6 kDa |
| Amino Acids | 263 aa |
| NCBI Gene ID | 5682 |
| Ensembl ID | ENSG00000129084 |
| GeneCards | PSMA1 |
| Human Protein Atlas | PSMA1 |
| Outer α-rings | Composed of PSMA1-7, forming the substrate entry gate |
| Inner β-rings | Composed of PSMB1-7, containing the proteolytic sites (PSMB5, PSMB6, PSMB7) |
| Proteolysis | The α-ring contributes to the structural integrity of the proteolytic chamber |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | AKT, ATG, CDKN1A, CDKN2A, DMSO, EIF4EBP1 |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
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