| Gene Symbol | PITX3 |
| Full Name | Pituitary Homeobox 3 |
| Chromosome | 10q24.31 |
| Protein Type | Transcription Factor |
| Target Class | Signaling Protein |
| Function | encodes a homeobox transcription factor critical for the development and survival of dopaminergic neurons. |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR |
| Primary Expression | diencephalic dopaminergic clusters |
| Subcellular Localization | </b></td><td>Nucleus</td></tr> |
| Druggability | Undruggable (0.20) |
| Molecular Weight | 43 kDa |
| Amino Acids | 394 aa |
| Pathways | insulin signaling |
| UniProt ID | O96038 |
| NCBI Gene ID | 5304 |
| Ensembl ID | ENSG00000107807 |
| OMIM | 602618 |
| GeneCards | PITX3 |
| Human Protein Atlas | PITX3 |
| Associated Diseases | als, ms, neurodegeneration, parkinson, Parkinson's disease |
| Known Drugs/Compounds | levodopa |
| Interactions | BCL2, DAT, EN1, EN2, FOXA2, LMX1A |
| SciDEX Target | View Target Profile |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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