concept

REPEAT-CONTAINING TRANSCRIPTS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REPEAT-CONTAINING TRANSCRIPTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

1Analyses

37Outgoing

21Incoming

0Experiments

1Debates

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💡 Concept Info

Name	REPEAT-CONTAINING TRANSCRIPTS
Key Genes/Proteins	AMYOTROPHIC LATERAL SCLEROSIS, AND, C9ORF72, DEMENTIA, DNA, GENES
Related Diseases	ALS, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia

Pathway Diagram

graph TD
    REPEAT_CONTAINING_TRANSCRIPTS["REPEAT-CONTAINING TRANSCRIPTS"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| Dementia["Dementia"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| ALS["ALS"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| Frontotemporal_Dementia["Frontotemporal Dementia"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"studied_in"| neurodegeneration["neurodegeneration"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| RNA["RNA"]
    REPEAT_CONTAINING_TRANSCRIPTS -->|"expressed in"| AND["AND"]
    DEMENTIA["DEMENTIA"] -->|"expressed in"| REPEAT_CONTAINING_TRANSCRIPTS
    HTT["HTT"] -->|"interacts"| REPEAT_CONTAINING_TRANSCRIPTS
    DMPK["DMPK"] -->|"interacts"| REPEAT_CONTAINING_TRANSCRIPTS
    Antisense_Oligonucleotide_Ther["Antisense Oligonucleotide Therapy"] -->|"references"| REPEAT_CONTAINING_TRANSCRIPTS
    CRISPR_Cas9_Gene_Therapy_for_N["CRISPR/Cas9 Gene Therapy for Neurodegeneration"] -->|"references"| REPEAT_CONTAINING_TRANSCRIPTS
    c9orf72_protein["c9orf72-protein"] -->|"references"| REPEAT_CONTAINING_TRANSCRIPTS

Outgoing (37)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:REPEAT-CONTAINING TRANSCRIPTS	data_in	dataset_row	0.00
Dementia	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Frontotemporal Dementia	expressed_in	disease	0.65
C9ORF72	expressed_in	gene	0.60
GENETIC MODIFIERS	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
RAN	associated_with	gene	0.60
AND	expressed_in	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
TNR	associated_with	gene	0.60
HUNTINGTIN	expressed_in	gene	0.60
Neuron	expressed_in	cell_type	0.55
Spinal Cord	expressed_in	brain_region	0.55
neurodegeneration	associated_with	disease	0.54
HTT	interacts_with	gene	0.54
DMPK	interacts_with	gene	0.54
PITX3	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
Cell-type-specific essential genes	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40

Incoming (21)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:REPEAT-CONTAINING TRANSCRIPTS	data_in	dataset_row	0.00
h-3a4f2027	targets_gene	hypothesis	0.90
DEMENTIA	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
HTT	interacts_with	gene	0.54
DMPK	interacts_with	gene	0.54
DMPK	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
Cell-type-specific essential genes	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
PGC1A	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40
c9orf72-protein	references	protein	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning REPEAT-CONTAINING TRANSCRIPTS in their description or question text

No additional research found