concept

CELL-TYPE-SPECIFIC ESSENTIAL GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL-TYPE-SPECIFIC ESSENTIAL GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

50Connections

1Hypotheses

1Analyses

31Outgoing

19Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CELL-TYPE-SPECIFIC ESSENTIAL GENES

Pathway Diagram

graph TD
    CELL_TYPE_SPECIFIC_ESSENTIAL_G["CELL-TYPE-SPECIFIC ESSENTIAL GENES"]
    CELL_TYPE_SPECIFIC_ESSENTIAL_G -->|"studied_in"| neurodegeneration["neurodegeneration"]
    CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| APOE_regulatory_regions["APOE regulatory regions"]
    CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| NURR1["NURR1"]
    CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| FOXO3["FOXO3"]
    CELL_TYPE_SPECIFIC_ESSENTIAL_G ---|"co-discussed"| PGC1A["PGC1A"]
    DMPK["DMPK"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
    PGC1A ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
    CREB1["CREB1"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
    repeat_containing_transcripts["repeat-containing transcripts"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G
    synaptic_plasticity_genes["synaptic plasticity genes"] ---|"co-discussed"| CELL_TYPE_SPECIFIC_ESSENTIAL_G

Outgoing (31)

Target	Relation	Type	Str
neurodegeneration	associated_with	disease	0.60
HTT, DMPK, repeat-containing transcripts	debate_co_mention	gene	0.45
NURR1, PITX3, neuronal identity transcription factors	debate_co_mention	gene	0.45
FOXO3	debate_co_mention	gene	0.45
LDLR	debate_co_mention	gene	0.45
PITX3	debate_co_mention	gene	0.45
HMGCR, LDLR, APOE regulatory regions	debate_co_mention	gene	0.45
Disease-causing mutations with integrated reporters	debate_co_mention	gene	0.45
RNA	debate_co_mention	gene	0.45
BDNF	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
repeat-containing transcripts	co_discussed	gene	0.40
PITX3	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes	co_associated_with	gene	0.40
NURR1, PITX3, neuronal identity transcription factors	co_associated_with	gene	0.40
Disease-causing mutations with integrated reporters	co_associated_with	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
PGC1A	co_discussed	gene	0.40
CRISPR	co_associated_with	gene	0.30

Incoming (19)

Source	Relation	Type	Str
h-63b7bacd	targets_gene	hypothesis	0.90
h-63b7bacd	targets	hypothesis	0.50
APOE	debate_co_mention	gene	0.45
BDNF	debate_co_mention	gene	0.45
BDNF, CREB1, synaptic plasticity genes	debate_co_mention	gene	0.45
HMGCR	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
PGC1A	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
repeat-containing transcripts	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Context-Dependent CRISPR Activation in Specific Neuronal Sub	0.682	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
Exploring Parkinson's through the Lens of Genomics and Bioinformatics. [PMID:39929729]	Menon V	Cold Spring Harb Perspect Med	2026	0
A Simple Method for RNA-Seq of Manually Isolated Chromatophores in Oryzias Fishe [PMID:41805030]	Goda M, Miyagi A, Sugiwaka K, Watanabe M	Dev Growth Differ	2026	0
Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associate [PMID:41576950]	["Ghoochani A", "Heiby J", "Rawat E", "M	Cell	2026	0
Decoding Alzheimer's genetic risk through intercellular communication in the hum [PMID:41707523]	Lish AM, Young-Pearse TL	Current opinion in neurobiolog	2026	0
Neuromodulatory role and therapeutic potential of N 6 -methyladenosine RNA methy [PMID:40618260]	Zhang J, Ma W, Liu R, Li X, Yuan Z, Chen	Neural regeneration research	2026	0
Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Progr [PMID:41676679]	Xie Y, Chang L, Zhong G, Rink JA, Báez-B	bioRxiv : the preprint server	2026	0
Metabolic rewiring prevents neurodegeneration caused by chronic mitochondrial dy [PMID:41151583]	Richhariya S, Shin D, Schlichting M, Ros	Current biology : CB	2025	0
Focused ultrasound widely broadens AAV-delivered Cas9 distribution and activity. [PMID:39893321]	Gumusgoz E, Kasiri S, Youssef I, Verma M	Gene therapy	2025	0
Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associate [PMID:39464040]	["Ghoochani A", "Heiby J", "Rawat E", "M	bioRxiv : the preprint server	2024	0
Amyloid-β specific regulatory T cells attenuate Alzheimer's disease pathobiology [PMID:38111016]	Yeapuri P, Machhi J, Lu Y, Abdelmoaty MM	Molecular neurodegeneration	2023	0
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activat [PMID:35526014]	Sudwarts A, Ramesha S, Gao T	Mol Neurodegener	2022	0
Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339]	Degrave J, Felici F, Buchli J, Neunert M	Nature	2022	0
Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF. [PMID:33199879]	Fernández-Ruiz I	Nature reviews. Cardiology	2021	0
SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center. [PMID:34469734]	Ou P, Stanek A, Huan Z, Roman CAJ, Huan	Cell reports	2021	0
Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor ant [PMID:33046621]	Razak AR, Cleary JM, Moreno V, Boyer M,	Journal for immunotherapy of c	2020	0
Functional characterization of 84 PALB2 variants of uncertain significance. [PMID:31636395]	Wiltshire T, Ducy M, Foo TK, Hu C, Lee K	Genetics in medicine : officia	2020	0
Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystroph [PMID:30778238]	Nelson CE, Wu Y, Gemberling MP, Oliver M	Nature medicine	2019	0
Rising hazard of storm-surge flooding. [PMID:29078412]	Stefan Rahmstorf	Proceedings of the National Ac	2017	0
Epigenome Editing in the Brain. [PMID:28523558]	Bashtrykov P, Jeltsch A	Advances in experimental medic	2017	0

Debates (1)

Multi-agent debates referencing this entity

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CELL-TYPE-SPECIFIC ESSENTIAL GENES in their description or question text

No additional research found