Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | EN1 |
| Protein Type | Transcription Factor |
| Function | Engrailed Homeobox 1 (EN1) is a member of the engrailed family of homeobox transcription factors that play critical roles in embryonic development of the central nervous system. |
| Amino Acids | 391 aa |
| GeneCards | EN1 |
| Human Protein Atlas | EN1 |
| Homeodomain | A 60-amino acid DNA-binding helix-turn-helix motif (positions 240-300) that recognizes and binds to specific DNA sequences (TAATTT) to regulate target gene transcription[@gehring1994] |
| Harmonin homology domains | Involved in protein-protein interactions with other transcription factors |
| Transactivation domain | Located at the N-terminus, activates transcription of target genes |
| Substantia nigra pars compacta | High expression in dopaminergic neurons (highest expression of all EN family members in SNc) |
| Ventral tegmental area | Expression in VTA dopaminergic neurons |
| Red nucleus | Expression in midbrain motor neurons |
| Cerebellum | Expression in Purkinje cells during development |
| Olfactory bulb | Expression in interneurons |
| Associated Diseases | neurodegeneration |
| Interactions | DAT, EN2, FOXA2, LMX1A, NURR1, PITX3 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EN1["EN1"]
EN2["EN2"]
EN1 -->|"activates"| EN2
FOXA2["FOXA2"]
EN1 -->|"activates"| FOXA2
LMX1A["LMX1A"]
EN1 -->|"activates"| LMX1A
NURR1["NURR1"]
EN1 -->|"activates"| NURR1
PITX3["PITX3"]
EN1 -->|"activates"| PITX3
TH["TH"]
EN1 -->|"activates"| TH
neurons(["neurons"])
EN1 -->|"expressed in"| neurons
DAT["DAT"]
DAT -->|"activates"| EN1
neurodegeneration["neurodegeneration"]
EN1 -->|"implicated in"| neurodegeneration
style EN1 fill:#1b5e20,stroke:#66bb6a,stroke-width:2px,color:#fff| Source | Relation | Type | Str |
|---|---|---|---|
| DAT | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EN1 in their description or question text
No additional research found