Contents

PITX3 Gene

🧬 Gene Info

Gene Symbol	PITX3
Full Name	Pituitary Homeobox 3
Chromosome	10q24.31
Protein Type	Transcription Factor
Target Class	Signaling Protein
Function	encodes a homeobox transcription factor critical for the development and survival of dopaminergic neurons.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Primary Expression	diencephalic dopaminergic clusters
Druggability	Undruggable (0.20)
Molecular Weight	43 kDa
Amino Acids	394 aa
Pathways	insulin signaling
UniProt ID	O96038
NCBI Gene ID	5304
Ensembl ID	ENSG00000107807
OMIM	602618
GeneCards	PITX3
Human Protein Atlas	PITX3
Associated Diseases	als, ms, neurodegeneration, parkinson, Parkinson's disease
Known Drugs/Compounds	levodopa
Interactions	BCL2, DAT, EN1, EN2, FOXA2, LMX1A
SciDEX Target	View Target Profile
KG Connections	62 knowledge graph edges
Databases	GeneCards HPA STRING

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