gene 1,377 words KG: PIEZO2
Contents

PIEZO2 — Piezo Type Mechanosensitive Ion Channel Component 2

🧬 Gene Info
Gene SymbolPIEZO2
Full NamePiezo Type Mechanosensitive Ion Channel Component 2
Chromosome18p11.22
Protein TypeChannel
Functionencodes a 2822-amino acid protein that forms functional homotrimeric channels.
Primary Expressiona highly cell-type-specific pattern in the nervous system:
Molecular Weight318 kDa
Amino Acids2822 aa
PathwaysApoptosis, Autophagy
UniProt IDQ9H5I5
NCBI Gene ID63895
Ensembl IDENSG00000154864
OMIM613629
GeneCardsPIEZO2
Human Protein AtlasPIEZO2
Associated DiseasesAls, Cancer, Cardiac, FIBROSIS, Labor Dysfunction, Ms
InteractionsAND, ANG, FAM38A, GENES, PIEZO, PIEZO1
KG Connections232 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (9)

blarcamesine-axon
clinical_trial · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
ANG — Angiogenin
gene · KG edge: activates
CACNA1B Gene
gene · KG edge: causes

Knowledge Graph (12 edges)

PIEZO2 participates_in MA_CATION_CHANNELS
PIEZO2 expressed_in DRG_NEURONS
PIEZO2 regulates pain
PIEZO2 regulates touch_sensation
PIEZO2 regulates proprioception
PIEZO2 expressed_in nervous_system
KCNK2 associated_with PIEZO2
SCN5A associated_with PIEZO2
TRPM7 associated_with PIEZO2
SCN1A associated_with PIEZO2

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