gene 783 words KG: NUCKS1
Contents

NUCKS1 Gene

🧬 Gene Info
Gene SymbolNUCKS1
Full NameNUCKS1, Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1
Chromosome1q32.1
Protein TypeKinase
FunctionNUCKS1 encodes a nuclear protein that serves as a substrate for several kinases, including casein kinases and cyclin-dependent kinases.
Primary Expressionneurons and glial cells, where it may play roles in neuronal survival and response to cellular stress
Molecular Weight66 kDa
PathwaysEpigenetic
UniProt IDQ9H0U4
NCBI Gene ID64766
Ensembl IDENSG00000138231
GeneCardsNUCKS1
Human Protein AtlasNUCKS1
Associated DiseasesALS, Ms, Parkinson
InteractionsActin, DNA, JUN, PARKINSON, PARKINSON'S DISEASE
KG Connections76 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

DNA Methylation
entity · KG edge: protects_against
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
Genes
index · KG edge: associated_with
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SNCA associated_with NUCKS1
SLC6A2 associated_with NUCKS1
JUN activates NUCKS1
SLC6A3 associated_with NUCKS1
SLC6A4 associated_with NUCKS1
NUCKS1 associated_with ABCB1
NUCKS1 associated_with APOE
NUCKS1 associated_with CYP2D6
GPNMB transports NUCKS1
NUCKS1 transports CYP2D6

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