gene 1,499 words KG: NPAS4
Contents

NPAS4 Gene

🧬 Gene Info
Gene SymbolNPAS4
Full NameNeuronal PAS domain protein 4
Chromosome19q13.3
Protein FamilybHLH-PAS transcription factor family
Protein TypeTranscription Factor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight102 kDa
Amino Acids892 aa
Exons9 exons
PathwaysAutophagy, Notch
GeneCardsNPAS4
Human Protein AtlasNPAS4
Chromosomal location19q13.3
Gene length~13 kb
mRNA length~2.8 kb
Associated Diseasesneurodegeneration
InteractionsApp, ARNT, AUTOPHAGY, BDNF, BRAIN INJURY, C-FOS
KG Connections69 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (18)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Oligodendrocyte White Matter Vulnerability
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
APLP1 Gene
gene · KG edge: regulates
APLP2 Gene
gene · KG edge: regulates
ARNT - Aryl Hydrocarbon Receptor Nuclear Translocator
gene · KG edge: activates

Knowledge Graph (12 edges)

APLP2 regulates NPAS4
APLP1 regulates NPAS4
NPAS4 regulates APP
HDAC3 inhibits NPAS4
ARNT activates NPAS4
HDAC3 activates NPAS4
NPAS4 activates STAT3
NPAS4 activates HDAC3
NPAS4 expressed_in BDNF
NPAS4 activates FOXP1

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